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KMID : 1100620220090020140
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Clinical and Experimental Emergency Medicine
2022 Volume.9 No. 2 p.140 ~ p.145
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Finding acute coronary syndrome with serial troponin testing for rapid assessment of cardiac ischemic symptoms (FAST-TRAC): a study protocol
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Peacock W. Frank
Maisel Alan S.
Mueller Christian
Anker Stefan D.
Apple Fred S.
Christenson Robert H.
Collinson Paul
Daniels Lori B.
Diercks Deborah B.
Di Somma Salvatore
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Abstract
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Objective: To determine the utility of a highly sensitive troponin assay when utilized in the emergency department.
Methods: The FAST-TRAC study prospectively enrolled >1,500 emergency department patients with suspected acute coronary syndrome within 6 hours of symptom onset and 2 hours of emergency department presentation. It has several unique features that are not found in the majority of studies evaluating troponin. These include a very early presenting population in whom prospective data collection of risk score parameters and the physician’s clinical impression of the probability of acute coronary syndrome before any troponin data were available. Furthermore, two gold standard diagnostic definitions were determined by a pair of cardiologists reviewing two separate data sets; one that included all local troponin testing results and a second that excluded troponin testing so that diagnosis was based solely on clinical grounds. By this method, a statistically valid head-to-head comparison of contemporary and high sensitivity troponin testing is obtainable. Finally, because of a significant delay in sample processing, a unique ability to define the molecular stability of various troponin assays is possible.
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KEYWORD
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Acute coronary syndrome, Troponin, Emergency medicine, Myocardial infarction, Coronary artery disease
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